S-(5'-Adenosyl)-L-methionine tosylate
Code | Size | Price |
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TAR-T4447-10mg | 10mg | £95.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4447-1mL | 1 mL * 10 mM (in DMSO) | £97.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4447-25mg | 25mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4447-50mg | 50mg | £124.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4447-100mg | 100mg | £140.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4447-200mg | 200mg | £181.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T4447-500mg | 500mg | £293.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
S-(5'-Adenosyl)-L-methionine (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases [1]. SAM (tosylate) (SAMe) is a stable salt of SAM that is included in nutritional supplements for oral use [2]. SAMe reportedly ameliorates depression, pain associated with osteoarthritis and fibromyalgia, and liver toxicity [3].
CAS:
52248-03-0
Formula:
C22H30N6O8S2
Molecular Weight:
570.64
Purity:
1
SMILES:
Cc1ccc(cc1)S([O-])(=O)=O.C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
References
Chiang P. Biological Effects of Inhibitors of S-Adenosylhomocysteine Hydrolase[J]. Pharmacology & Therapeutics, 1998, 77(2):115.
Berardis D D, Marini S, Serroni N, et al. S-Adenosyl-L-Methionine Augmentation in Patients with Stage II Treatment-Resistant Major Depressive Disorder: An Open Label, Fixed Dose, Single-Blind Study[J]. The Scientific World Journal,2013,(22013-5-12), 2013, 2013(5):204649.
Najm W I, Sibylle R, Fred H, et al. S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. [ISRCTN36233495][J]. Bmc Musculoskeletal Disorders, 2004, 5(1):6.
Jin C, Li Y, Su Y, et al. Novel copper complex CTB regulates methionine cycle induced TERT hypomethylation to promote HCC cells senescence via mitochondrial SLC25A26. Cell death & disease. 2020, 11(10): 1-15.
Jin C, Li Y, Su Y, et al. Novel copper complex CTB regulates methionine cycle induced TERT hypomethylation to promote HCC cells senescence via mitochondrial SLC25A26[J]. Cell death & disease. 2020, 11(10): 1-15.