Lumiracoxib
Code | Size | Price |
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TAR-T6574-1mL | 1 mL * 10 mM (in DMSO) | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
TAR-T6574-10mg | 10mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Quantity:
TAR-T6574-25mg | 25mg | £128.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6574-50mg | 50mg | £148.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6574-100mg | 100mg | £172.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6574-200mg | 200mg | £215.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.
CAS:
220991-20-8
Formula:
C15H13ClFNO2
Molecular Weight:
293.72
Pathway:
Neuroscience; Immunology/Inflammation
Purity:
0.9664
SMILES:
Cc1ccc(Nc2c(F)cccc2Cl)c(CC(O)=O)c1
Target:
COX
References
Jiao W, Zhao X, Wu G, et al. Bioactivation of Lumiracoxib in Human Liver Microsomes: Formation of GSH?and Amino Adducts Through Acyl Glucuronide[J]. Drug Testing and Analysis. 2020, 12(6): 827-835.
Esser R, et al. Br J Pharmacol, 2005, 144(4), 538-550.
Jiao W, Zhao X, Wu G, et al. Bioactivation of Lumiracoxib in Human Liver Microsomes: Formation of GSH?and Amino Adducts Through Acyl Glucuronide. Drug Testing and Analysis. 2020, 12(6): 827-835.
Sun J, Zhang L, Zhang L, et al. A validated UHPLC?MS/MS method for simultaneous determination of lumiracoxib and its hydroxylation and acyl glucuronidation metabolites in rat plasma: Application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis. 2021, 201: 114105.
Sun J, Zhang L, Zhang L, et al. A validated UHPLC-MS/MS method for simultaneous determination of lumiracoxib and its hydroxylation and acyl glucuronidation metabolites in rat plasma: application to a pharmacokinetic study[J]. Journal of Pharmaceutical and Biomedical Analysis. 2021: 114105.
Sun J, Zhang L, Zhang L, et al. A validated UHPLC-MS/MS method for simultaneous determination of lumiracoxib and its hydroxylation and acyl glucuronidation metabolites in rat plasma: application to a pharmacokinetic study. Journal of Pharmaceutical and Biomedical Analysis. 2021: 114105.