TargetMol

Rolipram

Product Code:
 
TAR-T6644
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T6644-10mg10mg£107.00
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TAR-T6644-1mL1 mL * 10 mM (in DMSO)£109.00
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TAR-T6644-50mg50mg£119.00
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TAR-T6644-100mg100mg£142.00
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TAR-T6644-200mg200mg£173.00
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This product comes from: United States.
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Further Information

Bioactivity:
Rolipram is a phosphodiesterase 4 inhibitor with antidepressant properties.
CAS:
61413-54-5
Formula:
C16H21NO3
Molecular Weight:
275.348
Pathway:
Metabolism; Proteases/Proteasome; Microbiology/Virology
Purity:
0.9926
SMILES:
COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1
Target:
HIV Protease; Antibacterial; PDE

References

MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36. Shalaby, A., & Kamal, S. (2012). Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on ?-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress.?J Pharmacol Pharmacother,?3(2), 132-7. doi: 10.4103/0976-500X.95509