Y15
Code | Size | Price |
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TAR-T7119-10mg | 10mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7119-50mg | 50mg | £132.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7119-100mg | 100mg | £184.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7119-200mg | 200mg | £240.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T7119-500mg | 500mg | £361.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.
CAS:
4506-66-5
Formula:
C6H14Cl4N4
Molecular Weight:
284.01
Pathway:
Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
Purity:
0.98
SMILES:
Cl.Cl.Cl.Cl.Nc1cc(N)c(N)cc1N
Target:
FAK
References
Hochwald S N , Nyberg C , Zheng M , et al. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer[J]. Cell Cycle, 2009, 8(15):2435-2443.
Hu S, Wang Z, Jin C, et al. Human amniotic epithelial cell-derived extracellular vesicles provide an extracellular matrix-based microenvironment for corneal injury repair. Journal of Tissue Engineering. 2022, 13: 20417314221122123
Sun Y, Qian Y, Chen C, et al. Extracellular vesicle IL-32 promotes the M2 macrophage polarization and metastasis of esophageal squamous cell carcinoma via FAK/STAT3 pathway. Journal of Experimental & Clinical Cancer Research. 2022, 41(1): 1-22
Zheng D , Golubovskaya V , Kurenova E , et al. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts[J]. Molecular Carcinogenesis, 2010, 49(2):0-0.
O'Brien S, Golubovskaya VM, Conroy J,et al.FAK inhibition with small molecule inhibitor Y15 decreases viability, clonogenicity, and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics[J].Oncotarget. 2014 Sep 15;5(17):7945-59.