ShK-Dap22
| Code | Size | Price |
|---|
| TAR-TP2123-10mg | 10mg | £1,981.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000 pM for hKV1.5, mKV1.7, hKV3.1, rKV3.4 and hKCa4). Suppresses T cell activation in vitro (IC50 < 500 pM).
CAS:
220384-25-8
Formula:
C166H268N54O48S7
Molecular Weight:
4012.7
Purity:
0.98
SMILES:
0
References
Kalman et al (1998) ShK-Dap22, a potent KV1.3-specific immunosuppresive polypeptide. J.Biol.Chem. 273 32697 PMID:
Robbins et al (2005) Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via KV1.3 channels. J.Physiol. 564 131 PMID: