Nicorandil
Code | Size | Price |
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TAR-T0075-50mg | 50mg | £99.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0075-100mg | 100mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0075-1mL | 1 mL * 10 mM (in DMSO) | £115.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0075-200mg | 200mg | £128.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Nicorandil(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods. Firstly, by activating potassium channels, and secondly by donating nitric oxide to activate the enzyme guanylate cyclase. Guanylate cyclase causes activation of cGMP leading to both arterial and venous vasodilatation by de-phosphorylation of the myosin light chain.
CAS:
65141-46-0
Formula:
C8H9N3O4
Molecular Weight:
211.177
Pathway:
Membrane transporter/Ion channel
Purity:
0.9944
SMILES:
[O-][N+](=O)OCCNC(=O)c1cccnc1
Target:
Potassium Channel
References
1. Sato T, et al. J Am Coll Cardiol, 2000, 35(2), 514-518.
2. Akao M, et al. J Am Coll Cardiol, 2002, 40(4), 803-810.
3. Szczepanik AM, et al. J Pharmacol Exp Ther, 1996, 278(2), 913-920.
4. Teshima Y, et al. Brain Res, 2003, 1990(1-2), 45-50.
5. Sathish V, et al. Mol Cell Biochem, 2003, 243(1-2), 133-138.