Docetaxel trihydrate
| Code | Size | Price |
|---|
| TAR-T0186-100mg | 100mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T0186-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor including breast and lung cancer. Therapy with docetaxel has been associated with a low rate of serum enzyme elevations and rarely to instances of acute hepatic necrosis generally due to severe hypersensitivity reactions or sepsis.
CAS:
148408-66-6
Formula:
C43H59NO17
Molecular Weight:
861.935
Pathway:
Apoptosis; Cytoskeletal Signaling
Purity:
1
SMILES:
O.O.O.CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@]1(C)[C@@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c3ccccc3)C(C)=C([C@@H](O)C1=O)C2(C)C
Target:
Apoptosis; BCL; Microtubule Associated
References
1. Buey RM. Chem Biol, 2004, 11(2), 225-236.
2. Riou JF, et al. Biochem Biophys Res Commun, 1992, 187(1), 164-170.
3. Balcer-Kubiczek EK, et al. Chemotherapy, 2006, 52(5), 231-240.
4. Silvestrini R, et al. Stem Cells, 1993, 11(6), 528-35.
5. Tanaka M, et al. Eur J Cancer. 1996, 32A(2), 226-330.