TargetMol

Reserpine

Product Code:
 
TAR-T0791
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T0791-50mg50mg£100.00
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TAR-T0791-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T0791-100mg100mg£115.00
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  • Further Information
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Further Information

Bioactivity:
Reserpine is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
CAS:
50-55-5
Formula:
C33H40N2O9
Molecular Weight:
608.68
Pathway:
Autophagy; Membrane transporter/Ion channel; ; Immunology/Inflammation
Purity:
0.996
SMILES:
CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c1cc(OC)c(OC)c(OC)c1
Target:
Potassium Channel; MRP; Monoamine Transporter; Autophagy

References

1. Schmitz FJ, et al. J Antimicrob Chemother, 1998, 42(6), 807-810. 2. Kannari K, et al. J Neurochem, 2000, 74(1), 263-269. 3. Ceccatelli S, et al. Brain Res Mol Brain Res, 1991, 9(1-2), 57-69. 4. Cai JX, et al. Brain Res, 1993, 614(1-2), 191-196. 5. Burger ME, et al. Brain Res, 2005, 1031(2), 202-210. 6. Antkiewicz-Michaluk L, et al. Withdrawal from repeated administration of a low dose of reserpine induced opposing adaptive changes in the noradrenaline and serotonin system function: a behavioral and neurochemical ex vivo and in vivo studies in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Mar 3;57:146-54. 7. Hong B, et al. Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway. AAPS J. 2016 May;18(3):659-69.