TargetMol

CMF019

Product Code:
 
TAR-T10843
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T10843-1mg1mg£168.00
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TAR-T10843-1mL1 mL * 10 mM (in DMSO)£278.00
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TAR-T10843-5mg5mg£279.00
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TAR-T10843-10mg10mg£422.00
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TAR-T10843-25mg25mg£643.00
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TAR-T10843-50mg50mg£862.00
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Quantity:
TAR-T10843-100mg100mg£1,131.00
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Further Information

Bioactivity:
CMF019 is a potent agonist of the Apelin receptor (APJ) with G protein bias. CMF019 binds to APJ (pKis: 8.58, 8.49, and 8.71 for the human, rat, and mouse).
CAS:
1586787-08-7
Formula:
C25H33N3O3S
Molecular Weight:
455.61
Pathway:
GPCR/G Protein
Purity:
0.9854
SMILES:
C(CC)(CC)N1C=2C(N=C1CC3=CC=CS3)=CC(C(N[C@@H](CC(C)C)CC(O)=O)=O)=CC2
Target:
Apelin receptor

References

1. Trifonov L, et al. An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist. Med Chem. 2018;14(7):688-694. 2. Read C, et al. Cardiac action of the first G protein biased small molecule apelin agonist. Biochem Pharmacol. 2016 Sep 15;116:63-72.