TargetMol

Dibutyryl-cGMP sodium

Product Code:
 
TAR-T11038
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11038-5mg5mg£304.00
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Quantity:
TAR-T11038-50mg50mg£1,026.00
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Quantity:
TAR-T11038-100mg100mg£1,532.00
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This product comes from: United States.
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Further Information

Bioactivity:
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analog. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits [3H]-arachidonic acid release in human platelets stimulated by gamma thrombin. Dibutyryl-cGMP sodium can induce peripheral analgesia by activating ATP-sensitive K + channels.
CAS:
51116-00-8
Formula:
C18H23N5NaO9P
Molecular Weight:
507.372
Purity:
0.98
SMILES:
CCCC(=O)Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(=O)(O[Na])O[C@H]2[C@H]1OC(=O)CCC

References

1. Bor?n MS, et al. The cyclic GMP-protein kinase G pathway regulates cytoskeleton dynamics and motility in astrocytes. J Neurochem. 2007 Jul;102(1):216-30. 2. Sane DC, et al. Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets. Biochem Biophys Res Commun. 1989 Dec 15;165(2):708-14. 3. Soares AC, et al. Dibutyryl-cyclic GMP induces peripheral antinociception via activation of ATP-sensitive K(+) channels in the rat PGE2-induced hyperalgesic paw. Br J Pharmacol. 2001 Sep;134(1):127-31.