Ciclopirox
Code | Size | Price |
---|
TAR-T1482-25mg | 25mg | £96.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1482-50mg | 50mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1482-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1482-100mg | 100mg | £121.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T1482-200mg | 200mg | £145.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Ciclopirox exerts its action by binding to and chelating trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential co-factors for enzymes. Ciclopirox is a synthetic, broad-spectrum antifungal agent with additional antibacterial and anti-inflammatory activities. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, the organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).
CAS:
29342-05-0
Formula:
C12H17NO2
Molecular Weight:
207.273
Pathway:
Membrane transporter/Ion channel; Microbiology/Virology; Apoptosis; Cell Cycle/Checkpoint; Autophagy
Purity:
0.9941
SMILES:
Cc1cc(C2CCCCC2)n(O)c(=O)c1
Target:
ATPase; Ferroptosis; Antibacterial; Autophagy; Antifungal
References
1. Linden T, et al. FASEB J,2003, 17(6), 761-763.
2. Sigle HC, et al. J Antimicrob Chemother,2005, 55(5), 663-673.
3. Lee SJ, et al. Br J Pharmacol,2005, 145(4), 469-476.
4. Choi JJ, et al. Neuropharmacology,2002, 43(3), 408-417.
5. Braga PC, et al. Arzneimittelforschung,1992, 42(11), 1368-1371.
6. Huang Y, Su R, Sheng Y, et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia[J]. Cancer Cell. 2019, 35(4): 677-691. e10.