IT-901
Code | Size | Price |
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TAR-T15601-5mg | 5mg | £304.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T15601-50mg | 50mg | £1,026.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T15601-100mg | 100mg | £1,524.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
IT-901 is an orally active and effective inhibitor of NF-κB subunit c-Rel (IC50s: 0.1 μM, 3 μM for NF-κB DNA binding and c-Rel DNA binding, respectively). IT-901 has the potential for human lymphoid tumors, and ameliorate graft-versus-host disease.
CAS:
1584121-99-2
Formula:
C17H14N2O4S
Molecular Weight:
342.37
Pathway:
NF-κb
Purity:
0.98
SMILES:
COc1cc(OC)c2ccccc2c1C=C1C(=O)NC(=S)NC1=O
Target:
NF-κB
References
1. Shono Y, et al. Characterization of a c-Rel Inhibitor That Mediates Anticancer Properties in HematologicMalignancies by Blocking NF-?B-Controlled Oxidative Stress Responses. Cancer Res. 2016 Jan 15;76(2):377-89.
2. Vaisitti T, et al. Targeting metabolism and survival in chronic lymphocytic leukemia and Richter syndrome cellsby a novel NF-?B inhibitor. Haematologica. 2017 Nov;102(11):1878-1889.