Rotigaptide
| Code | Size | Price |
|---|
| TAR-T16790-25mg | 25mg | £837.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Rotigaptide is a novel and specific modulator of Cx43 and is a potent AAP. Rotigaptide prevents the uncoupling of Cx43-mediated gap junction communication and normalizes cell-to-cell communication during acute metabolic stress.
CAS:
355151-12-1
Formula:
C28H39N7O9
Molecular Weight:
617.66
Purity:
0.98
SMILES:
C[C@@H](NC(=O)CNC(=O)[C@H]1C[C@H](O)CN1C(=O)[C@H]1CCCN1C(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)NCC(N)=O
References
1. Seyed Mojtaba?Ghiasi, et al. The connexin 43 regulator Rotigaptide reduces cytokine-induced cell death in human islets
2. Stahlhut M, et al. The antiarrhythmic peptide rotigaptide (ZP123) increases connexin 43 protein expression in neonatal rat ventricular cardiomyocytes.Cell Commun Adhes.?2006 Jan-Apr;13(1-2):21-7.
3. Kj?lbye AL, et al. Pharmacological?modulation?of?gap?junction?function?with the?novel?compound?rotigaptide: a?promising?new?principle?for?prevention?of?arrhythmias.Basic Clin Pharmacol Toxicol.?2007 Oct;101(4):215-30.