TargetMol

9-cis-Retinal

Product Code:
 
TAR-T19169
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T19169-1mL1 mL * 10 mM (in DMSO)£392.00
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TAR-T19169-5mg5mg£432.00
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TAR-T19169-10mg10mg£536.00
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TAR-T19169-25mg25mg£697.00
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Further Information

Bioactivity:
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to CRBP-I and CRBP-II (Kds: 8 nM and 5 nM). It expedites differentiation and maturation of rod photoreceptors in retinal organoids.
CAS:
514-85-2
Formula:
C20H28O
Molecular Weight:
284.443
Purity:
0.98
SMILES:
C/C(/C=C/C=C(/C)C=CC1=C(C)CCCC1(C)C)=CC=O

References

1. Kane MA, et al. Binding affinities of CRBPI and CRBPII for 9-cis-retinoids.Biochim Biophys Acta. 2011 May;1810(5):514-8. 2. Mertz JR, et al. Identification and characterization of a stereospecific human enzyme that catalyzes 9-cis-retinol oxidation. A possible role in 9-cis-retinoic acid formation. J Biol Chem. 1997 May 2;272(18):11744-9. 3. Kaya KD, et al. Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal. Mol Vis. 2019 Nov 11;25:663-678. 4. Parker RO, et al. Normal cone function requires the interphotoreceptor retinoid binding protein. J Neurosci. 2009 Apr 8;29(14):4616-21.