TargetMol

Parthenolide

Product Code:
 
TAR-T2140
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2140-1mL1 mL * 10 mM (in DMSO)£111.00
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TAR-T2140-50mg50mg£111.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T2140-100mg100mg£125.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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TAR-T2140-200mg200mg£166.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
CAS:
20554-84-1
Formula:
C15H20O3
Molecular Weight:
248.322
Pathway:
Autophagy; NF-κb; Apoptosis
Purity:
0.9946
SMILES:
CC1=C/CC[C@@]2(C)O[C@H]2[C@H]2OC(=O)C(=C)[C@@H]2CC1
Target:
Apoptosis; Mitophagy; NF-κB; Autophagy

References

1. Nakshatri, H., Appaiah, H., Anjanappa, M., Gilley, D., Tanaka, H., & Badve, S. et al. (2015). NF-?B-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT.?Cell Death & Disease,?6(1), e1608-e1608. doi: 10.1038/cddis.2014.569 2. Zhao X, et al. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014 Jan 6;33:3. 3. Barbier-Torres L, et al. Histone deacetylase 4 promotes cholestatic liver injury in the absence of prohibitin-1. Hepatology. 2015 Oct;62(4):1237-48.