Erythro-sphingosine, (+)-
| Code | Size | Price |
|---|
| TAR-T24044-25mg | 25mg | £1,225.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Erythro-sphingosine, (+)- is a cell-permeable and reversible inhibitor of protein kinase C (IC50: 12 μM) and enhances Src kinase activity.
CAS:
6036-75-5
Formula:
C18H37NO2
Molecular Weight:
299.499
Purity:
0.98
SMILES:
CCCCCCCCCCCCCC=C[C@H](O)[C@H](N)CO
References
1. Kong JN, Zhu Z, Itokazu Y, Wang G, Dinkins MB, Zhong L, Lin HP, Elsherbini A, Leanhart S, Jiang X, Qin H, Zhi W, Spassieva SD, Bieberich E. Novel function of ceramide for regulation of mitochondrial ATP release in astrocytes. J Lipid Res. 2018 Mar;59(3):488-506. doi: 10.1194/jlr.M081877. Epub 2018 Jan 10. PubMed PMID: 29321137; PubMed Central PMCID: PMC5832933.
2. Molinski TF, Broaddus CD, Morinaka BI. Liposomal Circular Dichroism (L-CD) of Arenoyl Derivatives of Sphingolipids. Amplification of Cotton Effects in Ordered Lipid Bilayers. Mar Drugs. 2017 Dec 20;15(12). pii: E352. doi: 10.3390/md15120352. PubMed PMID: 29261105; PubMed Central PMCID: PMC5742824.
3. Hassouneh LK, Timofiychuk OA, Babenko NA. Acid sphingomyelinase inhibitors, imipramine and zoledronic acid, increase skeletal muscle tissue sensitivity to insulin action at old age. Gen Physiol Biophys. 2018 Mar;37(2):163-174. doi: 10.4149/gpb_2017020. Epub 2017 Nov 10. PubMed PMID: 29125130.
4. Paz Ramos A, Gooris G, Bouwstra J, Lafleur M. Evidence of hydrocarbon nanodrops in highly ordered stratum corneum model membranes. J Lipid Res. 2018 Jan;59(1):137-143. doi: 10.1194/jlr.M080432. Epub 2017 Nov 1. PubMed PMID: 29092959; PubMed Central PMCID: PMC5748504.