Cilastatin
Code | Size | Price |
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TAR-T2583-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2583-25mg | 25mg | £116.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2583-50mg | 50mg | £136.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2583-100mg | 100mg | £172.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2583-200mg | 200mg | £238.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Cilastatin is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.
CAS:
82009-34-5
Formula:
C16H26N2O5S
Molecular Weight:
358.45
Pathway:
Ubiquitination; Proteases/Proteasome; Microbiology/Virology
Purity:
0.9971
SMILES:
S(C[C@H](N)C(=O)O)CCCC/C=C(NC(=O)[C@@H]1C(C1)(C)C)/C(=O)O
Target:
Proteasome; Antibacterial; Antibiotic
References
1. Farrell CA, et al. Arch Biochem Biophys. 1987 Jul;256(1):253-9.
2. Huo X, Meng Q, Wang C, et al. Protective effect of cilastatin against diclofenac?induced nephrotoxicity in mice through interaction with diclofenac acyl glucuronide via OATs[J]. British Journal of Pharmacology. 2020, 177(9): 1933-1948.