Eflornithine hydrochloride hydrate
Code | Size | Price |
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TAR-T2593-50mg | 50mg | £95.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2593-100mg | 100mg | £104.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2593-200mg | 200mg | £117.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T2593-500mg | 500mg | £170.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Eflornithine hydrochloride is a specific, irreversible inhibitor of ornithine decarboxylase.
CAS:
96020-91-6
Formula:
C6H15ClF2N2O3
Molecular Weight:
236.64
Pathway:
; Metabolism
Purity:
0.9964
SMILES:
O.Cl.NCCCC(N)(C(F)F)C(O)=O
Target:
Decarboxylase
References
1. Yoda H, et al. Plant Physiol. 2006, 142(1):193-206.
2. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52.
3. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202.
4. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501.
5. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312.
6. Dial C N. Modulation of Coxsackievirus Protease Activity by Polyamines[D]. Loyola University Chicago. 2019.
7. Dial C N, Tate P M, Kicmal T M, et al. Coxsackievirus B3 Responds to Polyamine Depletion via Enhancement of 2A and 3C Protease Activity[J]. Viruses. 2019 Apr 30;11(5).
8. Kicmal T M, Tate P M, Dial C N, et al. Polyamine depletion abrogates enterovirus cellular attachment[J]. Journal of virology. 2019, 93(20): e01054-19.
9. Mastrodomenico V, Esin J J, Graham M L, et al. Polyamine depletion inhibits bunyavirus infection via generation of noninfectious interfering virions[J]. Journal of virology. 2019 May 1. pii: JVI.00530-19.