Antipain dihydrochloride
| Code | Size | Price |
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| TAR-T26637-25mg | 25mg | £551.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Antipain HCl is a protease inhibitor found in Actinomycetes.
CAS:
37682-72-7
Formula:
C27H44N10O6
Molecular Weight:
604.713
Purity:
0.98
SMILES:
CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)NC(Cc1ccccc1)C(O)=O)C(=O)NC(CCCN=C(N)N)C=O
References
1. Nakae K, Kojima F, Sawa R, Kubota Y, Igarashi M, Kinoshita N, Adachi H, Nishimura Y, Akamatsu Y. Antipain Y, a new antipain analog that inhibits neurotransmitter release from rat dorsal root ganglion neurons. J Antibiot (Tokyo). 2010 Jan;63(1):41-4. doi: 10.1038/ja.2009.109. Epub 2009 Nov 13. PubMed PMID: 19911027.
2. Aguda AH, Lavallee V, Cheng P, Bott TM, Meimetis LG, Law S, Nguyen NT, Williams DE, Kaleta J, Villanueva I, Davies J, Andersen RJ, Brayer GD, Br?mme D. Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts. J Nat Prod. 2016 Aug 26;79(8):1962-70. doi: 10.1021/acs.jnatprod.6b00215. Epub 2016 Aug 6. PubMed PMID: 27498895.
3. Isogai E, Ishijima S, Sonoda T, Kita K, Suzuki H, Hasegawa R, Yamamori H, Takakubo Y, Suzuki N. Protease activation following UV irradiation is linked to hypomutability in human cells selected for resistance to combination of UV and antipain. Mutat Res. 1998 Jul 17;403(1-2):215-22. PubMed PMID: 9726021.
4. Souza-Silva F, Bourguignon SC, Pereira BA, C?rtes LM, de Oliveira LF, Henriques-Pons A, Finkelstein LC, Ferreira VF, Carneiro PF, de Pinho RT, Caffarena ER, Alves CR. Epoxy-?-lapachone has in vitro and in vivo anti-leishmania (Leishmania) amazonensis effects and inhibits serine proteinase activity in this parasite. Antimicrob Agents Chemother. 2015 Apr;59(4):1910-8. doi: 10.1128/AAC.04742-14. Epub 2015 Jan 12. PubMed PMID: 25583728; PubMed Central PMCID: PMC4356828.