MHY908
| Code | Size | Price |
|---|
| TAR-T28035-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28035-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28035-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MHY908, a novel inhibitor of melanogenesis, potently inhibits mushroom tyrosinase activity in a dose-dependent manner.
CAS:
1393371-39-5
Formula:
C17H14ClNO3S
Molecular Weight:
347.81
Purity:
0.98
SMILES:
CC(C)(Oc1ccc(cc1)-c1nc2cc(Cl)ccc2s1)C(O)=O
References
1. Kim YR, Lee EK, Kim DH, Kim KM, Lee B, An HJ, Park JW, Moon KM, Park MH, Chung KW, Park JY, Kim SJ, Yun HY, Son S, Chun P, Moon HR, Chung HY. PPAR? activation by MHY908 attenuates age-related renal inflammation through modulation of the ROS/Akt/FoxO1 pathway. Exp Gerontol. 2017 Jun;92:87-95. doi: 10.1016/j.exger.2017.03.015. Epub 2017 Mar 18. PubMed PMID: 28323024.
2. Park MH, Kim DH, Kim MJ, Lee EK, An HJ, Jeong JW, Kim HR, Kim SJ, Yu BP, Moon HR, Chung HY. Effects of MHY908, a New Synthetic PPAR?/? Dual Agonist, on Inflammatory Responses and Insulin Resistance in Aged Rats. J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):300-9. doi: 10.1093/gerona/glv043. Epub 2015 Jul 28. PubMed PMID: 26219845.
3. Park MH, Kim SJ, Jeong HO, Moon KM, Son S, Kim DH, Kim HR, Kim MJ, Yun HY, Chun P, Je NK, Yokozawa T, Moon HR, Chung HY. Inhibition of melanogenesis by 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908). Arch Pharm Res. 2015 Apr;38(4):505-11. doi: 10.1007/s12272-014-0532-0. Epub 2014 Dec 14. PubMed PMID: 25502981.
4. Park MH, Park JY, Lee HJ, Kim DH, Park D, Jeong HO, Park CH, Chun P, Moon HR, Chung HY. Potent anti-diabetic effects of MHY908, a newly synthesized PPAR ?/? dual agonist in db/db mice. PLoS One. 2013 Nov 14;8(11):e78815. doi: 10.1371/journal.pone.0078815. eCollection 2013. PubMed PMID: 24244369; PubMed Central PMCID: PMC3828319.