PD 404182
| Code | Size | Price |
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| TAR-T28348-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28348-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
PD-404182, an inhibitor of KDO 8-P synthase (Ki = 26 nM), is a otential antibiotic of gram negative bacteria. PD-404182 also exhibits antiviral and antiangiogenic activity in vitro.
CAS:
72596-74-8
Formula:
C11H11N3S
Molecular Weight:
217.29
Purity:
0.98
SMILES:
N=C1Sc2ccccc2C2=NCCCN12
References
1. Zhao C, Li T, Han B, Yue W, Shi L, Wang H, Guo Y, Lu Z. DDAH1 deficiency promotes intracellular oxidative stress and cell apoptosis via a miR-21-dependent pathway in mouse embryonic fibroblasts. Free Radic Biol Med. 2016 Mar;92:50-60. doi: 10.1016/j.freeradbiomed.2016.01.015. Epub 2016 Jan 21. PubMed PMID: 26806551.
2. Okazaki S, Oishi S, Mizuhara T, Shimura K, Murayama H, Ohno H, Matsuoka M, Fujii N. Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds. Org Biomol Chem. 2015 Apr 28;13(16):4706-13. doi: 10.1039/c5ob00301f. PubMed PMID: 25800792.
3. Okazaki S, Mizuhara T, Shimura K, Murayama H, Ohno H, Oishi S, Matsuoka M, Fujii N. Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold. Bioorg Med Chem. 2015 Apr 1;23(7):1447-52. doi: 10.1016/j.bmc.2015.02.015. Epub 2015 Feb 16. PubMed PMID: 25744188.
4. Chamoun-Emanuelli AM, Bobardt M, Moncla B, Mankowski MK, Ptak RG, Gallay P, Chen Z. Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide. Antimicrob Agents Chemother. 2014;58(2):687-97. doi: 10.1128/AAC.02000-13. Epub 2013 Nov 11. PubMed PMID: 24217696; PubMed Central PMCID: PMC3910842.