Biliatresone
| Code | Size | Price |
|---|
| TAR-T30451-25mg | 25mg | £837.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T30451-50mg | 50mg | £1,267.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Biliatresone is a very rare natural isoflavone-related 1, 2-diaryl-2-allenone found in Dysphania Glomulifera and D. littoralis. It has been found to cause extrahepatic biliary atresia in zebra fish models.
CAS:
1801433-90-8
Formula:
C18H16O6
Molecular Weight:
328.32
Purity:
0.98
SMILES:
COc1cc2OCOc2c(OC)c1C(=O)C(=C)c1ccccc1O
References
1. Zhao X, Lorent K, Wilkins BJ, Marchione DM, Gillespie K, Waisbourd-Zinman O, So J, Koo KA, Shin D, Porter JR, Wells RG, Blair I, Pack M. Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish. Hepatology. 2016 Sep;64(3):894-907. doi: 10.1002/hep.28603. Epub 2016 Jun 11. PubMed PMID: 27102575; PubMed Central PMCID: PMC5251204.
2. Waisbourd-Zinman O, Koh H, Tsai S, Lavrut PM, Dang C, Zhao X, Pack M, Cave J, Hawes M, Koo KA, Porter JR, Wells RG. The toxin biliatresone causes mouse extrahepatic cholangiocyte damage and fibrosis through decreased glutathione and SOX17. Hepatology. 2016 Sep;64(3):880-93. doi: 10.1002/hep.28599. Epub 2016 May 20. PubMed PMID: 27081925; PubMed Central PMCID: PMC4992464.
3. Koo KA, Waisbourd-Zinman O, Wells RG, Pack M, Porter JR. Reactivity of Biliatresone, a Natural Biliary Toxin, with Glutathione, Histamine, and Amino Acids. Chem Res Toxicol. 2016 Feb 15;29(2):142-9. doi: 10.1021/acs.chemrestox.5b00308. Epub 2016 Jan 13. PubMed PMID: 26713899; PubMed Central PMCID: PMC4757443.
4. Davenport M. Biliary atresia: From Australia to the zebrafish. J Pediatr Surg. 2016 Feb;51(2):200-5. doi: 10.1016/j.jpedsurg.2015.10.058. Epub 2015 Nov 4. Review. PubMed PMID: 26653951.