Pyrrolidinedithiocarbamate ammonium
| Code | Size | Price |
|---|
| TAR-T3147-50mg | 50mg | £102.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3147-100mg | 100mg | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3147-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T3147-200mg | 200mg | £134.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Pyrrolidinedithiocarbamate ammonium, a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.
CAS:
5108-96-3
Formula:
C5H12N2S2
Molecular Weight:
164.29
Pathway:
NF-κb
Purity:
0.98
SMILES:
N.SC(=S)N1CCCC1
Target:
NF-κB
References
1. Qin, J., Cao, Z., Li, X., Kang, X., Xue, Y., & Li, Y. et al. (2014). Effect of ammonium pyrrolidine dithiocarbamate (PDTC) on NF-?B activation and CYP2E1 content of rats with immunological liver injury.?Pharmaceutical Biology,?52(11), 1460-1466. doi: 10.3109/13880209.2014.898075
2. Gao Y, Elamin E, Zhou R, et al. FKBP51 promotes migration and invasion of papillary thyroid carcinoma through NF??B?dependent epithelial?to?mesenchymal transition[J]. Oncology letters. 2018 Dec;16(6):7020-7028.
3. Lu S, Luo Y, Sun G B, et al. Ginsenoside compound K attenuates ox-LDL-mediated macrophage inflammation and foam cell formation via autophagy induction and modulating NF-?B, p38, and JNK MAPK signaling[J]. Frontiers in Pharmacology. 2020, 11.
4. Zhao L, Xia M, Wang K, et al. A Long Non-coding RNA IVRPIE Promotes Host Antiviral Immune Responses Through Regulating Interferon ?1 and ISG Expression[J]. Frontiers in Microbiology. 2020, 11: 260.
5. Shi F1, Deng Z1, Zhou Z2, Jiang CY1, Zhao RZ1, Sun F1,3, Cui D1,3, Bei XY1,3, Yang BY1, Sun Q2, Wang XJ1,3, Wu Q2, Xia SJ1,3, Han BM1,3. QKI?6 inhibits bladder cancer malignant behaviours through down?regulating E2F3 and NF??B signalling. Journal of cellular and molecular medicine.
6. Li Y, Niu M, Zhao A, et al. CXCL12 is involved in ?-synuclein-triggered neuroinflammation of Parkinson?s disease[J]. Journal of Neuroinflammation. 2019, 16(1): 1-14.