Pemetrexed disodium hemipenta hydrate
Code | Size | Price |
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TAR-T6226-50mg | 50mg | £99.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6226-100mg | 100mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6226-200mg | 200mg | £128.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T6226-500mg | 500mg | £166.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Pemetrexed Disodium Hydrate is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is 1.3 nM, 7.2 nM and 65 nM, respectively.
CAS:
357166-30-4
Formula:
C20H21N5O6?2Na?5/2H2O
Molecular Weight:
518.43
Pathway:
DNA Damage/DNA Repair; Autophagy; Cell Cycle/Checkpoint; Apoptosis; Metabolism
Purity:
0.9916
SMILES:
OC(CC[C@@H](C(O)=O)NC(C(C=C1)=CC=C1CCC2=CNC(NC(N)=N3)=C2C3=O)=O)=O.OC(CC[C@@H](C(O)=O)NC(C(C=C4)=CC=C4CCC5=CNC(NC(N)=N6)=C5C6=O)=O)=O.[Na].O.[Na].O.[Na].O.[Na].O.O
Target:
Apoptosis; DHFR; DNA/RNA Synthesis; Antifolate; Autophagy
References
Teicher BA, et al. Clin Cancer Res. 2000, 6(3), 12016-1023.
Shih C, et al. Cancer Res. 1997, 57(6), 1116-1123.
Iwahori K, et al. Int J Cancer. 2012, doi: 10.1002/ijc.27611.
Bi G, Liang J, Zhao M, et al. MiR-6077 promotes cisplatin/pemetrexed resistance in lung adenocarcinoma by targeting CDKN1A/cell cycle arrest and KEAP1/ferroptosis pathways. Molecular Therapy-Nucleic Acids. 2022
Zhao G, Liang J, Shan G, et al.KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4.Communications Biology.2023, 6(1): 570.