TargetMol

2,5-Dihydroxyacetophenone

Product Code:
 
TAR-TCS2170
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-TCS2170-50mg50mg£95.00
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TAR-TCS2170-100mg100mg£107.00
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TAR-TCS2170-1mL1 mL * 10 mM (in DMSO)£111.00
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Further Information

Bioactivity:
1. 2, 5-Dihydroxyacetophenone possess anti-anxiety, and neuroprotective qualities. 2. 2, 5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. 3. 2, 5-Dihydroxyacetophenone has anti-inflammatory activity in activated macrophages, raising the possibility that this compound has a therapeutic potential for inflammatory conditions. 4. 2, 5-Dihydroxyacetophenone is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity in vitro in 3-isobutyl-1-methylxanthin-stimulated B16 mouse melanoma cells or in vivo in zebrafish and mouse models.
CAS:
490-78-8
Formula:
C8H8O3
Molecular Weight:
152.149
Pathway:
NF-κb; Proteases/Proteasome; MAPK
Purity:
0.9991
SMILES:
CC(=O)c1cc(O)ccc1O
Target:
ERK; NF-κB; Tyrosinase

References

Han Y , Jung H W , Lee J Y , et al. 2,5-Dihydroxyacetophenone Isolated from Rehmanniae Radix Preparata Inhibits Inflammatory Responses in Lipopolysaccharide-Stimulated RAW264.7 Macrophages[J]. Journal of Medicinal Food, 2012, 15(6):505-510.