Thalidomide
| Code | Size | Price |
|---|
| TAR-T0213-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T0213-200mg | 200mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T0213-500mg | 500mg | £148.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
CAS:
50-35-1
Formula:
C13H10N2O4
Molecular Weight:
258.233
Pathway:
Apoptosis; Autophagy
Purity:
0.9988
SMILES:
O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12
Target:
Apoptosis; TNF; Autophagy
References
1. D'Amato RJ, et al. Proc Natl Acad Sci U S A, 1994, 91(9), 4082-4085.
2. Sampaio EP, et al. J Exp Med, 1991, 173(3), 699-703.
3. Moreira AL, et al. J Exp Med, 1993, 177(6), 1675-1680.
4. Hideshima T, et al. Blood, 2000, 96(9), 2943-2950.
5. Haslett PA, et al. J Exp Med, 1998, 187(11), 1885-1892.
6. Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-?/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453.
7. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.
8. Guo Y, Fan Y, Pei X. Fangjihuangqi Decoction inhibits MDA?MB?231 cell invasion in vitro and decreases tumor growth and metastasis in triple?negative breast cancer xenografts tumor zebrafish model[J]. Cancer Medicine. 2020, 9(7): 2564-2578.