Acetohexamide
| Code | Size | Price |
|---|
| TAR-T0816-25mg | 25mg | £94.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T0816-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Acetohexamide is an intermediate-acting, first-generation sulfonylurea with hypoglycemic activity. It inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2) with Ki values of 22.9 and 14.2 μM in HEK293 cells transfected with the human receptor and in rat brain, respectively. Acetohexamide is metabolized in the liver to its active metabolite hydroxyhexamide.
CAS:
968-81-0
Formula:
C15H20N2O4S
Molecular Weight:
324.4
Pathway:
Metabolism; Membrane transporter/Ion channel
Purity:
0.9985
SMILES:
CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1
Target:
Potassium Channel; NADPH
References
1. Aldawsari H, et al. Int J Pharm. 2013 Sep 10;453(2):315-21.
2. McMahon RE, et al. The nature of the metabolites of acetohexamide in the rat and in the human. J Pharmacol Exp Ther. 1965 Aug;149(2):272-9.
3. Imamura Y, et al. Hypoglycemic effect of S(-)-hydroxyhexamide, a major metabolite of acetohexamide, and its enantiomer R(+)-hydroxyhexamide. Life Sci. 2001 Sep 7;69(16):1947-55.
4. Gopalakrishnan M, et al. Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells. Br J Pharmacol. 2000 Apr;129(7):1323-32.