Cyclosporin A
Code | Size | Price |
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TAR-T0945-50mg | 50mg | £99.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0945-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0945-100mg | 100mg | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0945-200mg | 200mg | £124.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Cyclosporine A is a Calcineurin Inhibitor Immunosuppressant. The mechanism of action of cyclosporine is as a Calcineurin Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor.
CAS:
59865-13-3
Formula:
C62H111N11O12
Molecular Weight:
1202.635
Pathway:
Microbiology/Virology; Metabolism; Immunology/Inflammation
Purity:
0.9985
SMILES:
CCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
Target:
Phosphatase; Antibiotic; Complement System
References
1. Handschumacher RE, et al. Science, 1984, 226(4674), 544-547.
2. Liu J, et al. Cell, 1991, 66(4), 807-815.
3. Fruman DA, et al. PNAS, 1992, 89(9), 3686-3690.
4. Flanagan WM, et al. Nature, 1991, 352(6338), 803-807.
5. Nicolli A, et al. J Biol Chem, 1996, 271(4), 2185-2192.
6. Liu J, Giri B R, Chen Y, et al. Schistosoma japonicum IAP and Teg20 safeguard tegumental integrity by inhibiting cellular apoptosis[J]. PLoS neglected tropical diseases. 2018 Jul 25;12(7):e0006654.
7. Song J, Zou D, Zhao X, et al. Bufalin inhibits human diffuse large B-cell lymphoma tumorigenesis by inducing cell death through the Ca2+/NFATC1/cMYC pathway[J]. Carcinogenesis. 2020
8. Song J, Zou D, Zhao X, et al. Bufalin inhibits human diffuse large B cell lymphoma tumorigenesis by inducing cell death through the Ca 2+/NFATC1/cMYC pathway[J]. Carcinogenesis. 2020