Monensin
| Code | Size | Price |
|---|
| TAR-T1033L-50mg | 50mg | £892.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with deregulated Wnt signaling.
CAS:
17090-79-8
Formula:
C36H62O11
Molecular Weight:
670.881
Purity:
0.98
SMILES:
CCC1(CCC(O1)C1(C)CCC2(CC(O)C(C)C(O2)C(C)C(OC)C(C)C(O)=O)O1)C1OC(CC1C)C1OC(O)(CO)C(C)CC1C
References
1. Abrar A, Tsukahara T, Kondo M, Ban-Tokuda T, Chao W, Matsui H. Effect of monensin withdrawal on rumen fermentation, methanogenesis and microbial populations in cattle. Anim Sci J. 2015 Sep;86(9):849-54. doi: 10.1111/asj.12368. Epub 2015 Mar 17. PubMed PMID: 25782058.
2. Linneen SK, McGee AL, Cole JR, Jennings JS, Stein DR, Horn GW, Lalman DL. Supplementation of monensin and Optimase to beef cows consuming low-quality forage during late gestation and early lactation. J Anim Sci. 2015 Jun;93(6):3076-83. doi: 10.2527/jas.2014-8406. PubMed PMID: 26115293.
3. Antonenko YN, Rokitskaya TI, Huczy?ski A. Electrogenic and nonelectrogenic ion fluxes across lipid and mitochondrial membranes mediated by monensin and monensin ethyl ester. Biochim Biophys Acta. 2015 Apr;1848(4):995-1004. doi: 10.1016/j.bbamem.2015.01.005. Epub 2015 Jan 17. PubMed PMID: 25600660.
4. Rocha BA, de Oliveira AR, Pazin M, Dorta DJ, Rodrigues AP, Berretta AA, Peti AP, de Moraes LA, Lopes NP, Posp??il S, Gates PJ, Assis Md. Jacobsen catalyst as a cytochrome P450 biomimetic model for the metabolism of monensin A. Biomed Res Int. 2014;2014:152102. doi: 10.1155/2014/152102. Epub 2014 May 28. PubMed PMID: 24987668; PubMed Central PMCID: PMC4058456.