DB1976 dihydrochloride
| Code | Size | Price |
|---|
| TAR-T10964L-5mg | 5mg | £370.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T10964L-50mg | 50mg | £1,468.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T10964L-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
DB1976 hydrochloride is a selenium selenium analogue of DB270, a potent and permeable cell transcription factor PU.1 inhibitor. In vitro, DB1976 hydrochloride effectively inhibited PU.1 binding (IC50 of 10 nM) and strongly inhibited PU.1 / DNA complex (with high DB1976-λB affinity, KD of 12 nM). DB1976 hydrochloride has the effect of inducing apoptosis.
CAS:
2369663-93-2
Formula:
C20H18Cl2N8Se
Molecular Weight:
520.29
Purity:
0.98
SMILES:
Cl.Cl.NC(=N)c1ccc2nc([nH]c2c1)-c1ccc([se]1)-c1nc2ccc(cc2[nH]1)C(N)=N
References
1. Munde M, et al. Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines. Nucleic Acids Res. 2014 Jan;42(2):1379-90.
2. Stephens DC, et al. Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis. Nucleic Acids Res. 2016 May 19;44(9):4005-13.
3. Antony-Debr? I, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017 Dec 1;127(12):4297-4313.