TargetMol

DSR-6434

Product Code:
 
TAR-T11108
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T11108-1mL1 mL * 10 mM (in DMSO)£148.00
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TAR-T11108-5mg5mg£148.00
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TAR-T11108-10mg10mg£203.00
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TAR-T11108-25mg25mg£324.00
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This product comes from: United States.
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Further Information

Bioactivity:
DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.
CAS:
1059070-10-8
Formula:
C19H28N8O2
Molecular Weight:
400.48
Pathway:
Immunology/Inflammation
Purity:
0.9912
SMILES:
O=C1NC=2C(=NC(=NC2N1CC3=CN=C(OCCN(C)C)C=C3)NCCCC)N
Target:
TLR

References

Nakamura T, et al. Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg Med Chem Lett. 2013 Feb 1;23(3):669-72. Adlard AL, et al. A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int J Cancer. 2014 Aug 15;135(4):820-9.