TargetMol

Ilorasertib hydrochloride

Product Code:
 
TAR-T11638
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
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TAR-T11638-50mg50mg£704.00
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TAR-T11638-100mg100mg£1,131.00
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Further Information

Bioactivity:
Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).
CAS:
1847485-91-9
Formula:
C25H22ClFN6O2S
Molecular Weight:
525
Pathway:
Cell Cycle/Checkpoint; Chromatin/Epigenetic
Purity:
0.98
SMILES:
Cl.Nc1ncc(-c2cnn(CCO)c2)c2scc(-c3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Target:
Aurora Kinase

References

1. Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.