CCT020312

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TargetMol
Product Code: TAR-T14902
Supplier: TargetMol
CodeSizePrice
TAR-T14902-1mg1mg£121.00
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TAR-T14902-5mg5mg£188.00
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TAR-T14902-10mg10mg£275.00
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TAR-T14902-25mg25mg£415.00
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Quantity:
TAR-T14902-50mg50mg£581.00
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Quantity:
TAR-T14902-100mg100mg£780.00
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TAR-T14902-500mg500mg£1,540.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
CCT020312 is a selective activator of EIF2AK3/PERK and elicits EIF2A phosphorylation in cells.
CAS:
324759-76-4
Formula:
C31H30Br2N4O2
Molecular Weight:
650.415
Pathway:
Apoptosis
Purity:
0.98
SMILES:
CCN(CC)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O
Target:
PERK

References

1. Stockwell SR, et al.Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling. PLoS One. 2012;7(1):e28568. 2. Bruch J, et al. PERK activation mitigates tau pathology in vitro and in vivo. EMBO Mol Med. 2017 Mar;9(3):371-384.