DB04760

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TargetMol
Product Code: TAR-T15055
Supplier: TargetMol
CodeSizePrice
TAR-T15055-1mg1mg£148.00
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TAR-T15055-5mg5mg£257.00
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TAR-T15055-1mL1 mL * 10 mM (in DMSO)£285.00
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TAR-T15055-10mg10mg£346.00
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TAR-T15055-25mg25mg£536.00
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TAR-T15055-50mg50mg£736.00
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TAR-T15055-100mg100mg£994.00
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TAR-T15055-500mg500mg£1,902.00
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Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

Images

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Documents

Further Information

Bioactivity:
DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activity.
CAS:
544678-85-5
Formula:
C22H20F2N4O2
Molecular Weight:
410.425
Pathway:
Proteases/Proteasome
Purity:
0.98
SMILES:
Cc1cc(CNC(=O)c2cc(ncn2)C(=O)NCc2ccc(F)c(C)c2)ccc1F
Target:
MMP

References

1. Engel CK, et al. Structural basis for the highly selective inhibition of MMP-13. Chem Biol. 2005 Feb;12(2):181-9. 2. Thomas S. Lisse, et al. Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15): E2189?E2198.