TargetMol

Istaroxime hydrochloride

Product Code:
 
TAR-T15599
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T15599-5mg5mg£256.00
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TAR-T15599-50mg50mg£704.00
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TAR-T15599-100mg100mg£1,018.00
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Further Information

Bioactivity:
Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
CAS:
374559-48-5
Formula:
C21H33ClN2O3
Molecular Weight:
396.96
Purity:
0.98
SMILES:
Cl.[H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC(=O)[C@@]2([H])CC(CC[C@]12C)=NOCCN

References

1. Gobbini M, et al. Novel analogues of istaroxime, a potent inhibitor of Na+,K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51(15):4601-8. 2. Gobbini M, et al. Novel analogues of Istaroxime, a potent inhibitor of Na(+),K(+)-ATPase: Synthesis, structure-activity relationship and 3D-quantitative structure-activity relationship of derivatives at position 6 on the androstane scaffold. Bioorg Med Ch 3. Micheletti R, et al. Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744). J Pharmacol Exp Ther. 2002 Nov;303(2):592-600.