TargetMol

Isotretinoin

Product Code:
 
TAR-T1611
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T1611-50mg50mg£99.00
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Quantity:
TAR-T1611-1mL1 mL * 10 mM (in DMSO)£111.00
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Quantity:
TAR-T1611-100mg100mg£111.00
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TAR-T1611-200mg200mg£124.00
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This product comes from: United States.
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Further Information

Bioactivity:
Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturally-occurring retinoic acid with potential antineoplastic activity. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
CAS:
4759-48-2
Formula:
C20H28O2
Molecular Weight:
300.442
Pathway:
Metabolism; Autophagy
Purity:
0.9961
SMILES:
CC(C=CC1=C(C)CCCC1(C)C)=C/C=C/C(/C)=CC(O)=O
Target:
Retinoid Receptor; Endogenous Metabolite; Autophagy

References

1. Webster WS, et al. J Craniofac Genet Dev Biol, 1986, 6(3), 211-222. 2. Smith-Thomas L, et al. Dev Biol, 1987, 123(1), 276-281. 3. Dopheide MM, et al. Pharmacol Biochem Behav, 2008, 91(2), 243-251. 4. Sieving PA, et al. Proc Natl Acad Sci U S A, 2001, 98(4), 1835-1840. 5. Radu RA, et al. Proc Natl Acad Sci U S A, 2003, 100(8), 4742-4747. 6. Qiu Y, Sun Y, Xu D, et al. Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue[J]. EBioMedicine. 2018, 37: 344-355.