PF-06372865
| Code | Size | Price |
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| TAR-T16489-100mg | 100mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T16489-50mg | 50mg | Enquire | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
PF-06372865 is a high-affinity ligand at GABAA receptors containing α1/α2/α3/α5 subunits (Kis: 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively). It also has a low affinity for α4/α6 subunits. PF-06372865 is an orally active and α2/α3/α5 subtype-selective GABAA positive allosteric modulator. PF-06372865 has the potential for epilepsy.
CAS:
1614245-70-3
Formula:
C22H21FN4O3S
Molecular Weight:
440.49
Purity:
0.98
SMILES:
CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)CC
References
1. Owen RM, et al. Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865). J Med Chem. 2019 Jun 27;62(12):5773-5796.