TargetMol

Tanaproget

Product Code:
 
TAR-T16985
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T16985-50mg50mg£743.00
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Quantity:
TAR-T16985-100mg100mg£1,187.00
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This product comes from: United States.
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Further Information

Bioactivity:
Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins (IC50: 0.1 nM),
CAS:
304853-42-7
Formula:
C16H15N3OS
Molecular Weight:
297.38
Purity:
0.98
SMILES:
Cn1c(ccc1-c1ccc2NC(=S)OC(C)(C)c2c1)C#N

References

1. Bruner-Tran KL, et al. Down-regulation of endometrial matrix metalloproteinase-3 and -7 expression in vitro and therapeutic regression of experimental endometriosis in vivo by a novel nonsteroidal progesterone receptor agonist, tanaproget. J Clin Endocrinol Metab. 2006 Apr;91(4):1554-60. 2. Zhang Z, et al. Molecular and pharmacological properties of a potent and selective novel nonsteroidal progesterone receptor agonist tanaproget. J Biol Chem. 2005 Aug 5;280(31):28468-75. 3. Bapst JL, et al. Pharmacokinetics and safety of tanaproget, a nonsteroidal progesterone receptor agonist, in healthy women. Contraception. 2006 Nov;74(5):414-8.