Sodium Oxamate
| Code | Size | Price |
|---|
| TAR-T19831-1g | 1g | £96.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis through enhancement of mitochondrial ROS generation.It inhibits L(+)-lactate dehydrogenase and derails the entire gluconeogenic pathway.
CAS:
565-73-1
Formula:
C2H2NNaO3
Molecular Weight:
111.032
Pathway:
Metabolism; Apoptosis; Cell Cycle/Checkpoint
Purity:
0.98
SMILES:
[Na+].NC(=O)C([O-])=O
Target:
Apoptosis; Dehydrogenase; CDK
References
1. Awasthi D , Nagarkoti S , Sadaf S , et al. Glycolysis dependent lactate formation in neutrophils: A metabolic link between NOX-dependent and independent NETosis[J]. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019, 1865(12):165542-.
2. A A Y , A C O , B R J M A . Lactate dehydrogenase supports lactate oxidation in mitochondria isolated from different mouse tissues[J]. Redox Biology, 28.