Methysergide maleate
| Code | Size | Price |
|---|
| TAR-T21423-5mg | 5mg | £2,938.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T21423-50mg | 50mg | £5,838.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T21423-100mg | 100mg | £8,344.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Methysergide is used for prophylaxis of migraine headaches/cluster headaches but is no longer recommended due to retropulmonary/retroperitoneal fibrosis. It may also be used in the treatment of serotonin syndrome. It is also used in carcinoid syndrome to treat severe diarrhea.
CAS:
129-49-7
Formula:
C25H31N3O6
Molecular Weight:
469.538
Purity:
0.98
SMILES:
OC(=O)C=C/C(O)=O.[H][C@@]12Cc3cn(C)c4cccc(C1=C[C@H](CN2C)C(=O)N[C@@H](CC)CO)c34
References
1. Valic M, Pecotic R, Pavlinac Dodig I, Valic Z, Stipica I, Dogas Z. Intermittent hypercapnia-induced phrenic long-term depression is revealed after serotonin receptor blockade with methysergide in anaesthetized rats. Exp Physiol. 2016 Feb 1;101(2):319-31. doi: 10.1113/EP085161. Epub 2015 Dec 20. PubMed PMID: 26621042.
2. David RB, Roncari CF, Lauar MR, Vendramini RC, Antunes-Rodrigues J, Menani JV, De Luca LA Jr. Sodium intake, brain c-Fos protein and gastric emptying in cell-dehydrated rats treated with methysergide into the lateral parabrachial nucleus. Physiol Behav. 2015 Nov 1;151:111-20. doi: 10.1016/j.physbeh.2015.07.014. Epub 2015 Jul 11. PubMed PMID: 26171591.
3. Andr?jak M, Szymanski C, Mar?chaux S, Arnalsteen E, Gras V, R?madi JP, Tribouilloy C. Valvular heart disease associated with long-term treatment by methysergide: a case report. Therapie. 2014 May-Jun;69(3):255-7. doi: 10.2515/therapie/2014030. Epub 2014 Jun 18. PubMed PMID: 24934823.
4. Matsuta Y, Schwen Z, Mally AD, Shen B, Wang J, Roppolo JR, de Groat WC, Tai C. Effect of methysergide on pudendal inhibition of micturition reflex in cats. Exp Neurol. 2013 Sep;247:250-8. doi: 10.1016/j.expneurol.2013.05.006. Epub 2013 May 18. PubMed PMID: 23688680; PubMed Central PMCID: PMC3742625.