GSK J5

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TargetMol
Product Code: TAR-T22821
Supplier: TargetMol
CodeSizePrice
TAR-T22821-1mg1mg£102.00
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TAR-T22821-1mL1 mL * 10 mM (in DMSO)£166.00
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TAR-T22821-5mg5mg£173.00
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TAR-T22821-10mg10mg£242.00
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Quantity:
TAR-T22821-25mg25mg£450.00
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TAR-T22821-50mg50mg£624.00
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TAR-T22821-100mg100mg£860.00
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TAR-T22821-500mg500mg£1,653.00
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Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
GSK J5 is an inactive isomer of GSK J4 and a cell-permeable ester derivative of inactive control GSK J2.
CAS:
1394854-51-3
Formula:
C24H27N5O2
Molecular Weight:
417.513
Pathway:
Chromatin/Epigenetic
Purity:
0.98
SMILES:
CCOC(=O)CCNc1cc(nc(n1)-c1cccnc1)N1CCc2ccccc2CC1
Target:
Histone Demethylase

References

Horton JR, et al. Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb 5;291(6):2631-46. Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2.