TargetMol

JNJ 10191584 maleate

Product Code:
 
TAR-T22879
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T22879-1mg1mg£138.00
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TAR-T22879-2mg2mg£172.00
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TAR-T22879-5mg5mg£217.00
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TAR-T22879-10mg10mg£252.00
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TAR-T22879-25mg25mg£470.00
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TAR-T22879-50mg50mg£651.00
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TAR-T22879-100mg100mg£863.00
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This product comes from: United States.
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Further Information

Bioactivity:
JNJ 10191584 maleate is an orally active and selective antagonist of H4 receptor (Ki = 26 nM). JNJ 10191584 maleate inhibits chemotaxis of eosinophils and mast cells (IC50 = 530 nM and 138 nM).
CAS:
869497-75-6
Formula:
C17H19ClN4O5
Molecular Weight:
394.81
Pathway:
Immunology/Inflammation; GPCR/G Protein; Neuroscience
Purity:
0.9982
SMILES:
C(=CC(O)=O)C(O)=O.C(=O)(C=1NC=2C(N1)=CC=C(Cl)C2)N3CCN(C)CC3
Target:
Histamine Receptor

References

1. Sanna MD, et al. Histamine H4 receptor stimulation in the locus coeruleus attenuates neuropathic pain by promoting the coeruleospinal noradrenergic inhibitory pathway. Eur J Pharmacol. 2020 Feb 5;868:172859. 2. Venable JD, et al. Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem. 2005 Dec 29;48(26):8289-98.