Gabaculine HCl
| Code | Size | Price |
|---|
| TAR-T24080-5mg | 5mg | £1,251.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24080-50mg | 50mg | £2,464.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T24080-100mg | 100mg | £3,283.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Gabaculine is an irreversible inhibitor of GABA transaminase (GABA-T; Ki: 2.9 μM). Gabaculine alters plastid development and differentially affects the abundance of plastid-encoded DPOR and nuclear-encoded GluTR.
CAS:
59556-17-1
Formula:
C7H10ClNO2
Molecular Weight:
175.61
Purity:
0.98
SMILES:
Cl.NC1CC(=CC=C1)C(O)=O
References
1. Bellucci M, De Marchis F, Ferradini N, Pompa A, Veronesi F, Rosellini D. A mutant Synechococcus gene encoding glutamate 1-semialdehyde aminotransferase confers gabaculine resistance when expressed in tobacco plastids. Plant Cell Rep. 2015 Dec;34(12):2127-36. doi: 10.1007/s00299-015-1856-z. Epub 2015 Aug 12. PubMed PMID: 26265112.
2. Demko V, Pavlovic A, Hud?k J. Gabaculine alters plastid development and differentially affects abundance of plastid-encoded DPOR and nuclear-encoded GluTR and FLU-like proteins in spruce cotyledons. J Plant Physiol. 2010 Jun 15;167(9):693-700. doi: 10.1016/j.jplph.2009.12.008. Epub 2010 Feb 2. PubMed PMID: 20129699.
3. Orriss GL, Patel TR, Sorensen J, Stetefeld J. Absence of a catalytic water confers resistance to the neurotoxin gabaculine. FASEB J. 2010 Feb;24(2):404-14. doi: 10.1096/fj.09-138297. Epub 2009 Sep 28. PubMed PMID: 19786580.
4. Irifune M, Katayama S, Takarada T, Shimizu Y, Endo C, Takata T, Morita K, Dohi T, Sato T, Kawahara M. MK-801 enhances gabaculine-induced loss of the righting reflex in mice, but not immobility. Can J Anaesth. 2007 Dec;54(12):998-1005. PubMed PMID: 18056209.