MS-1020
| Code | Size | Price |
|---|
| TAR-T28113-5mg | 5mg | £850.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28113-50mg | 50mg | £1,661.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T28113-100mg | 100mg | £2,079.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
MS-1020 is a JAK3 and STAT3 inhibitor. MS-1020 selectively blocks constitutively-active JAK3 and consistently suppressed interleukin-2-induced JAK3/STAT5 signalling. MS-1020 potently inhibits persistently-active STAT3 in a cell type-specific manner.
CAS:
1255516-86-9
Formula:
C21H18N2O3
Molecular Weight:
346.386
Purity:
0.98
SMILES:
Oc1ccc2[nH]cc(CCNC(=O)c3ccc4ccccc4c3O)c2c1
References
1. Kim BH, Oh SR, Yin CH, Lee S, Kim EA, Kim MS, Sandoval C, Jayabose S, Bach EA, Lee HK, Baeg GH. MS-1020 is a novel small molecule that selectively inhibits JAK3 activity. Br J Haematol. 2010 Jan;148(1):132-43. doi: 10.1111/j.1365-2141.2009.07925.x. Epub 2009 Sep 29. PubMed PMID: 19793252; PubMed Central PMCID: PMC3034357.
2. Sinclair CT, Kalender-Rich JL, Griebling TL, Porter-Williamson K. Palliative Care of Urologic Patients at End of Life. Clin Geriatr Med. 2015 Nov;31(4):667-78. doi: 10.1016/j.cger.2015.07.002. Review. PubMed PMID: 26476123.
3. Lemon RN, Mantel GW. The influence of changes in discharge frequency of corticospinal neurones on hand muscles in the monkey. J Physiol. 1989 Jun;413:351-78. PubMed PMID: 2600855; PubMed Central PMCID: PMC1189105.
4. Carmody J, Pawlak M, Messlinger K. Lack of a role for substance P in the control of dural arterial flow. Exp Brain Res. 1996 Oct;111(3):424-8. PubMed PMID: 8911936.