H-1152 dihydrochloride

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TargetMol
Product Code: TAR-T35328
Supplier: TargetMol
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TAR-T35328-1mg1mg£117.00
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TAR-T35328-2mg2mg£138.00
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TAR-T35328-5mg5mg£187.00
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TAR-T35328-1mL1 mL * 10 mM (in DMSO)£197.00
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TAR-T35328-10mg10mg£290.00
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TAR-T35328-25mg25mg£494.00
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TAR-T35328-50mg50mg£685.00
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TAR-T35328-100mg100mg£930.00
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TAR-T35328-500mg500mg£1,797.00
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Overview

Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃

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Documents

Further Information

Bioactivity:
H-1152 dihydrochloride is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 uM, 5.68 uM, 0.360 uM, 0.745 uM and 0.180 uM, respectively.
CAS:
871543-07-6
Formula:
C16H23Cl2N3O2S
Molecular Weight:
392.34
Pathway:
Stem Cells; Tyrosine Kinase/Adaptors; Cell Cycle/Checkpoint; Neuroscience; Chromatin/Epigenetic; Cytoskeletal Signaling
Purity:
0.98
SMILES:
Cl.Cl.C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(C)c12
Target:
CaMK; ROCK; PKA; PKC; Aurora Kinase

References

Tamura M, et al. Development of specific Rho-kinase inhibitors and their clinical application. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):245-52. Epub 2005 Sep 12.??Content Brief Lie M, et al. Accelerated neurite growth from spiral ganglion neurons exposed to the Rho kinase inhibitor H-1152. Neuroscience. 2010 Aug 25;169(2):855-62.??Content Brief Ikenoya M, et al. Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor. J Neurochem. 2002 Apr;81(1):9-16.??Content Brief