Norcholic Acid
| Code | Size | Price |
|---|
| TAR-T37177-50mg | 50mg | £684.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4
CAS:
60696-62-0
Formula:
C23H38O5
Molecular Weight:
394.5
Purity:
0.98
SMILES:
C[C@@]12[C@](CC[C@]2([H])[C@@H](CC(O)=O)C)([H])[C@@]3([H])[C@@](C[C@@H]1O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C[C@H]3O)C
References
Bremmelgaard, A., and Sj?vall, J.Bile acid profiles in urine of patients with liver diseasesEur. J. Clin. Invest.9(5)341-348(1979)
Pilo de la Fuente, B., Sobrido, M.J., Gir?s, M., et al.Usefulness of cholestanol levels in the diagnosis and follow-up of patients with cerebrotendinous xanthomatosisNeurologia26(7)397-404(2011)
Kuramoto, T., Furukawa, Y., Nishina, T., et al.Identification of short side chain bile acids in urine of patients with cerebrotendinous xanthomatosisJ. Lipid Res.101895-1902(1990)
Nakatomi, F., Kihira, K., Kuramoto, T., et al.Intestinal absorption and metabolism of norcholic acid in ratsJ. Pharmacobiodyn8(7)557-563(1985)