NS 6740
| Code | Size | Price |
|---|
| TAR-T37390-50mg | 50mg | £982.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
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Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
High affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory.
CAS:
753499-14-8
Formula:
C19H19F3N2O2.HCl
Molecular Weight:
400.82
Purity:
0.98
SMILES:
O=C(N1CCN2CCC1CC2)C(O3)=CC=C3C4=CC(C(F)(F)F)=CC=C4.Cl
References
Briggs et al (2009) Role of channel activation in cognitive enhancement mediated by ?7 nicotinic acetylcholine receptors. Br.J.Pharmacol. 158 1486 PMID:19845675
Papke et al (2015) The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor. Neuropharmacology 91 34 PMID:25497451
Thomsen et al (2012) The ?7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-? release from microglia. J.Neuroimmunol. 251 65 PMID:22884467