Disulfiram
| Code | Size | Price |
|---|
| TAR-T0054-1mL | 1 mL * 10 mM (in DMSO) | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T0054-1g | 1g | £111.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
CAS:
97-77-8
Formula:
C10H20N2S4
Molecular Weight:
296.52
Pathway:
Metabolism; Apoptosis; Immunology/Inflammation
Purity:
0.98
SMILES:
CCN(CC)C(=S)SSC(=S)N(CC)CC
Target:
Dehydrogenase; Interleukin; Pyroptosis
References
1. Chen D, et al. Cancer Res, 2006, 66(21), 10425-10433.
2. Wang W, et al. Int J Cancer, 2003, 104(4), 504-511.
3. Cen D, et al. J Med Chem, 2004, 47(27), 6914-6920.
4. Brar SS, et al. Mol Cancer Ther, 2004, 3(9), 1049-1060.
5. Bowden G D, Land K M, O'Connor R M, et al. High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth[J]. International Journal for Parasitology: Drugs and Drug Resistance. 2018 Apr?8(1): 137-144.
6. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.