Sunitinib
Code | Size | Price |
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TAR-T0374L-100mg | 100mg | £113.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0374L-200mg | 200mg | £136.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
TAR-T0374L-500mg | 500mg | £148.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Images
Documents
Further Information
Bioactivity:
Sunitinib, a multi-targeted RTK inhibitor, is targeting PDGFRβ and VEGFR2 (Flk-1) with IC50 of 2 nM and 80 nM and also inhibits c-Kit.
CAS:
557795-19-4
Formula:
C22H27FN4O2
Molecular Weight:
398.482
Pathway:
Autophagy; Tyrosine Kinase/Adaptors; Apoptosis; Angiogenesis; Cell Cycle/Checkpoint
Purity:
0.9967
SMILES:
CCN(CC)CCNC(=O)c1c(C)[nH]c(C=C2/C(=O)Nc3ccc(F)cc23)c1C
Target:
Apoptosis; Mitophagy; VEGFR; FLT; IRE1; PDGFR; c-Kit; Autophagy
References
1. Sun L, et al. J Med Chem, 2003, 46(7), 1116-1119.
2. Mendel DB, et al. Clin Cancer Res, 2003, 9(1), 327-337.
3. O'Farrell AM, et al. Blood, 2003, 101(9), 3597-3605.
4. Abrams TJ, et al. Mol Cancer Ther, 2003, 2(10), 1011-1021.
5. Yee KW, et al. Blood, 2004, 104(13), 4202-4209.