Carbimazole
| Code | Size | Price |
|---|
| TAR-T0952-500mg | 500mg | £107.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
| TAR-T0952-1mL | 1 mL * 10 mM (in DMSO) | £109.00 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
cool pack
Storage:
-20℃
Documents
Further Information
Bioactivity:
Carbimazole is an imidazole antithyroid agent. It is only found in individuals that have used or taken this drug. Carbimazole is metabolized to methimazole, which is responsible for the antithyroid activity. Carbimazole is an antithyroid agent that decreases the uptake and concentration of inorganic iodine by the thyroid, it also reduces the formation of di-iodotyrosine and thyroxine. Once converted to its active form of methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4.
CAS:
22232-54-8
Formula:
C7H10N2O2S
Molecular Weight:
186.23
Pathway:
Endocrinology/Hormones
Purity:
0.9922
SMILES:
CCOC(=O)n1ccn(C)c1=S
Target:
Thyroid hormone receptor(THR)
References
1. Taurog A, et al. Endocrinology, 1976, 98(4), 1031-1046.
2. Magnusson RP, et al. J Biol Chem, 1984, 259(1), 197-205.